MarvSip Capsule Filters for Steaming in Place

Order MarvSip Capsule Filters for Steaming in Place from MS factory when your pharmaceutical or biotech process requires a capsule filter that can be sterilized in place with steam without disassembly. The MarvSip series has a standard filter sealed in a robust plastic housing that remains high strength and integral at harsh applications, typically for steaming in place sterilization. Available in multiple media choices including PTFE, PES, and Nylon membranes to match specific application requirements for sterile air and liquid filtration.

The purpose designed SIP construction distinguishes it from conventional capsule filters that may not withstand repeated steaming in place cycles. The robust plastic housing maintains high strength and integrity under elevated temperatures and pressure cycling. Sanitary flange connections support easy integration with process equipment, providing reliable sealing and cleanability. The on line connection to automatic integrity testers supports routine verification without disassembly, essential for batch release documentation and regulatory compliance. With cost effective operation, multiple membrane options, and reliable performance under repeated SIP cycles, the MarvSip series provides a dependable filtration solution for sterile pharmaceutical and biotech manufacturing.

Technical Specifications

Construction Materials

• Filter Membrane: PTFE, PES, Nylon (multiple choices available)

• Media Support: Polypropylene

• End Caps: Polypropylene

• Inner Core: Polypropylene

• Outer Cage: Polypropylene

• Housing: Robust plastic designed for SIP conditions

Key Design Features and Benefits

•  Purpose designed for SIP. Specifically designed for steaming in place sterilization, with robust plastic housing that maintains high strength and integrity under harsh application conditions including repeated steam cycles, elevated temperatures, and pressure cycling.

•  Cost saving operation. Compared to stainless steel filter housings requiring significant capital investment and ongoing maintenance, provides a cost effective alternative for sterile filtration applications requiring SIP capability.

•  Easy connection with sanitary flange. Sanitary flange connections support easy integration into pharmaceutical and biotech process equipment, providing reliable sealing and cleanability that meets hygiene requirements.

•  On line connection to automatic integrity tester. Allows operators to verify filter integrity before and after use without disassembly, essential for batch release documentation and regulatory compliance.

•  Available in multiple choice of media and ratings. PTFE, PES, and Nylon membrane options with various pore size ratings to match specific application requirements for sterile air and liquid filtration.

Membrane Selection Guide for Different Applications

The selection of membrane type depends on specific application requirements, process fluid characteristics, and operating conditions. For gas and venting applications where hydrophobic behavior and broad chemical compatibility are required, PTFE membrane is typically preferred. For liquid filtration applications where low protein binding and high flow rates are important, particularly for biological products and cell culture media, PES membrane is frequently selected. For general liquid filtration applications where naturally hydrophilic behavior and strong flow characteristics in aqueous services are desired, Nylon membrane provides a reliable option. Our technical team can help determine the optimal membrane type and pore size rating based on specific application requirements.

Application Notes for Pharmaceutical and Biotech Processes

•  Sterile filtration of air and liquid. Designed for sterile filtration of both air and liquid in pharmaceutical and biological product manufacturing, with multiple membrane options. SIP capability allows sterilization in place without disassembly.

•  Fermenter and bioreactor sterile air filtration. PTFE membrane provides reliable sterile air filtration with high flow rates at low pressure drop. SIP capability allows sterilization in place between fermentation batches.

•  Sterile tank and vessel venting. PTFE membrane provides sterile air filtration for tank venting, and hydrophobic nature prevents liquid wetting through during tank filling or high humidity conditions.

•  Sterile liquid filtration for parenteral and biological products. PES membrane provides low protein binding and high flow rates. SIP capability allows sterilization in place before use, and on line integrity tester connection supports batch release documentation.

Toxicity and Biological Safety

All components meet USP Class VI 121 degree C biological safety specifications for plastics, supporting use in pharmaceutical, biotech, and food contact applications. This certification ensures filter materials do not leach toxic substances or cause adverse biological reactions when in contact with pharmaceutical products, biological materials, or food and beverage products.

SIP Cycle Guidance and Performance Expectations

•  Typical SIP cycle parameters. Circulating steam through the filter at 121 degree C or higher for a defined period, typically 30 minutes or longer depending on specific application requirements and regulatory standards.

•  Cooling and inspection. Filter should be allowed to cool gradually after SIP cycle to avoid thermal shock, and housing should be inspected for any signs of damage or deformation before returning to service.

•  Manufacturer recommendations. Important to follow equipment manufacturer recommendations for SIP cycle parameters including temperature, pressure, duration, and ramp rates to ensure sterility is achieved without compromising filter performance.

•  Cycle life. Under typical SIP conditions of 121 degree C for 30 minutes per cycle, the filter withstands multiple cycles before performance may be affected. Monitor performance and integrity regularly after repeated SIP cycles, replace if any decline is observed. Our technical team can provide guidance on expected cycle life and replacement scheduling for MarvSip Capsule Filters for Steaming in Place in your specific application.

Integrity Testing and Batch Release Documentation

•  On line integrity testing. Supports on line connection to automatic integrity testers for routine verification without disassembly. Pre use and post use integrity tests are commonly required for batch release documentation in sterile pharmaceutical manufacturing.

•  Test methods and support. Methods include bubble point testing and diffusion testing, standard methods for verifying membrane integrity. Our technical team can provide guidance on test protocols, test fluid selection, parameters, and acceptance criteria based on membrane type and pore size rating for MarvSip Capsule Filters for Steaming in Place.

Installation, Operation, and Maintenance Guidance

•  Before installation. Inspect filter for shipping damage, verify membrane type, pore size rating, and connection style match application requirements.

•  Installation. Install with correct flow orientation as indicated on housing, tighten sanitary flange connections per equipment manufacturer specs. Perform SIP sterilization per site SOP, then perform pre use integrity testing before placing into normal operation.

•  Operation. Monitor differential pressure across the filter and flow rate to ensure they remain within acceptable limits. Replace if differential pressure exceeds site defined terminal value or if integrity testing indicates filter failure.

•  Maintenance and replacement. Designed for easy removal and replacement using sanitary flange connections, simplifying changeout and reducing downtime. After removal, dispose of used filter per site waste management procedures, particularly if in contact with pharmaceutical or biological products.

•  Record keeping. Record installation dates, SIP cycle counts, integrity test results, differential pressure readings, and replacement dates to build performance history for each filter, supporting predictive maintenance scheduling and regulatory compliance.

Quality Documentation and Factory Support

•  Quality documentation. Integrity test reports per batch, USP Class VI certificates, material compliance statements, food contact declarations, and complete batch traceability. Additional packages available including sterilization validation guidance, recommended SIP and CIP cycle parameters, and integrity test method validation support.

•  Technical support. Membrane type and pore size selection, housing dimension and connection style matching, SIP and CIP cycle parameter development, integrity test protocol configuration, and changeout interval optimization based on specific process conditions.

•  Supply and customization. In house membrane production and capsule assembly enable dependable batch consistency and predictable delivery. OEM options include custom dimensions, connection configurations, membrane material selections, and private label branding. MarvSip Capsule Filters for Steaming in Place provide dependable performance and technical support for sterilization in place applications that demand robust performance and regulatory compliance.

Ordering Information